Sudden stoppage of oxycontin can result in serious withdrawal symptoms. The withdrawal syndrome may be characterized by restlessness, lacrimation, restlessness, anxiety, rhinorrhea, yawning, perspiration, chills, myalgia, and mydriasis. Other symptoms also may develop, include irritability, vague pain, weakness, abdominal cramps, insomnia, nausea, anorexia, vomiting, diarrhea, or increased blood pressure, respiratory rate, or heart rate.
Side effects
Respiratory depression is a severe complication of oxycontin. Respiratory depression is a cause of concern in elderly or debilitated patients, and usually follows after the use of large initial doses in non tolerant patients, or when other opioids are given concurrently. In the community, the majority of OxyContin-related deaths have occurred in individuals who were ingesting large quantities of oxycontin in combination with either alcholol or benzodiazepines.
Oxycontin should be used with extreme caution in patients with significant lung disorders such as chronic obstructive pulmonary disease, heart failure or pre-existing respiratory depression. In such patients, even usual therapeutic dose of oxycontin may suppress the respiratory drive to the point of arrest.
OxyContin may cause severe hypotension. There is an added risk to individuals whose ability to maintain blood pressure has been compromised by a depleted blood volume, or after concurrent administration with drugs such as phenothiazines or other agents which compromise vasomotor tone. Oxycontin, should be administered with caution to patients in circulatory shock, since vasodilatation produced by the drug may further reduce cardiac output and blood pressure.
Like other opioid narcotics, oxycontin can be fatal at high doses or when combined with other brain depressants such as alcohol.
Precautions
Oxycontin, like all opioid analgesics, has a narrow therapeutic index in certain patient populations, especially in those taking other CNS depressant drugs. Its use should be reserved for cases where the benefits of opioid analgesia outweigh the known risks of respiratory depression, altered mental state, and postural hypotension. The administration of oxycontin may obscure the diagnosis or clinical course in patients with acute abdominal conditions. Oxycontin may aggravate convulsions in patients with seizure disorders.